20-Bio-B6 Analytical Biochemistry, December 2019: worked solutions

Paper format: National Exams, December 2019 — 04-Bio-B6 Bioinstrumentation. Three hours, open book, non-communicating calculator permitted. Six questions of equal value (25 marks each); four constitute a complete paper and only the first four appearing in the answer book are marked. All six are solved here as a complete study resource. Every question is a design/essay question (block-diagram instrumentation-system design, or descriptive explanation).

Note — marking details

Q3(iv)'s marks belong to Q4(i)'s 12-mark opening sub-part, not to Q3; Q5(ii) and (iii) each carry their own 5 marks rather than a combined total; Q6(ii) covers the instrumentation for the whole ICU bedside monitor, not the pulse oximeter alone.

Reference texts (the books a candidate should have reviewed for this subject):

J. G. Webster (ed.), Medical Instrumentation: Application and Design — biopotential amplifiers, transducers, patient safety/isolation, pulse oximetry, phonocardiography and cardiovascular instrumentation.
J. Enderle, S. Blanchard & J. Bronzino, Introduction to Biomedical Engineering — bioinstrumentation systems, signal acquisition and noise.
J. T. Bushberg et al., The Essential Physics of Medical Imaging — MRI spatial encoding, CT and MRI spatial-resolution characterization and shielding.
IEC 60601 series, Medical Electrical Equipment — General Requirements for Basic Safety (adopted in Canada as CSA C22.2 No. 601) — macroshock/microshock leakage-current limits by applied-part classification.

20-Bio-B6 Analytical Biochemistry: December 2019